Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival

Background: Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV these patients. Objectives: To investigate presence and clinical significance of antibodies levels plasma obtained brain tumors. Materials Methods: HCMV-specific IgG IgM antibody were determined 59 collected tumor included a prospective study 114 healthy individuals. We examined if specific varied different diagnoses compared individuals, predictive for survival time. Results: by ELISA 80% 89% GBM astrocytoma grades II–III, respectively, all (100%) secondary metastases, as well donors (n = 114). All negative HCMV-IgM. Patients metastases who had higher HCMV-IgG titers longer times (p 0.03). Conclusions: among patient groups donors, except GBM. Higher not primary tumors associated prolonged